หมวดวิชาทักษะวิชาชีพ/กลุ่มทักษะวิชาชีพเฉพาะ
This review article aims to summarize what is understood in regards to the intricate job of p62 in inflammation and inflammation-connected diseases, like most cancers. The focus is over the underlying molecular mechanisms and pathways. Portion 2 describes the area construction of p62, its post-translational modifications, and interacting proteins. In Section 3, we focus on the function of p62 for a receptor in autophagy and its regulation, and in Area four, its involvement in signaling pathways, specifically inflammasomes (Section 4.
แอป เบราว์เซอร์ และอุปกรณ์ต่างๆ ของคุณ
หมายถึงหนังสือที่มีสาระอิงหลักสูตร
บางครั้งจะต้องดูสีสดใสไปจากข้อเท็จจริงบ้าง
หนังสือสำหรับเด็กไม่ควรมีโครงเรื่องที่ซับซ้อนมาก มีความสั้น กระชับ แต่คมคาย
หนังสือจัดชุดสำหรับศูนย์พัฒนาเด็กเล็ก
and p62. Domain architecture of p62, posttranslational modifications, binding/modifying proteins and pathways regulated by p62. The PB1 area mediates oligomerization and activation of p62, UBA-mediated dimerization holds p62 inactive. For phase separation, the PB1 and UBA domains are demanded. The position of p62 like a cargo receptor in autophagy is mediated from the LIR motif, linking it to LC3 on autophagosomes, and the UBA area, which binds to ubiquitinated cargos. Upon phosphorylation at Ser349, the KIR motif interacts with Keap1, thus liberating Nrf2 and inducing Nrf2 focus on gene expression. When Raptor binds to p62, mTOR is activated inducing metabolic pathways.
Since the carboxy terminal UBA (ubiquitin affiliated) area binds and thus recruits ubiquitinated proteins selected for autophagosomal degradation, p62 functions as being a cargo receptor for selective autophagy.
The tumor suppressor p53 is yet another significant protein linking autophagy with apoptosis. Autophagy could be induced by DNA problems through
เช่น เราวิเคราะห์วิธีที่ผู้คนโต้ตอบกับโฆษณาเพื่อปรับปรุงประสิทธิภาพโฆษณาของเรา
ขั้นตอนหรือชุดกฎที่ควบคุมให้คอมพิวเตอร์ดำเนินการแก้ไขปัญหา
The p62 protein is an attractive paradigm for complexity in molecular biology. Via its area construction, p62 interacts with a number of proteins regulating key pathways demanded p62 for the upkeep of homeostasis of cells and tissues, in addition to for inflammation and customary disorders which include most cancers (Figure four). It is likely that further more novel binding companions of p62 that happen to be critically involved in other pathways are going to be unveiled in the future. A recent case in point would be the identification of a role of extracellular p62 being an inflammatory mediator in sepsis [185]. p62 is actively secreted from macrophages and monocytes by secretory lysosomes or passively launched by pyroptotic cells and binds to the insulin receptor. This will cause NF-κB activation and in turn polarization of macrophages contributing to septic Dying [186]. There is absolutely no have to declare that p62 calls for a specific posttranslational modification (in sort of phosphorylation at Ser403) for this function in sepsis [186]. Whilst investigation in the past has discovered that p62 is modified and regulated by phosphorylation, ubiquitination, acetylation, proteolytic processing, plus the formation of disulfide bridges, we're considerably far from specifically comprehending how the binding of p62 to its a lot of interaction companions is regulated.
ควรเขียนในรูปแอบแฝงแทรกอยู่ในความสนุกสนาน หรือเรียกว่ารูปแบบ “สาระบันเทิง”